Department of Dermatology (CHUV/DHURDV), Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland.
- Page(s) : 546-7
- Année de parution : 2000
Acantholysis between keratinocytes in the epidermis is the cardinal histological
sign found in pemphigus. This autoimmune induced phenomenon is responsible
for the transient bulla and the erosions commonly found in the disease.
If the group of the desmogleins is now well known to be the target antigen,
the mechanism of induction and of development of pemphigus is still speculative.
It has, however, been noted that various triggering factors may [...]