European Journal of Dermatology
MENUNuclear receptor peroxisome proliferator activated receptor (PPAR) β/δ in skin wound healing and cancer Volume 25, supplément 1, April 2015
Auteurs
1 INRA ToxAlim Integrative Toxicology and Metabolism UMR1331, Chemin de Tournefeuille, Toulouse Cedex, France
2 Center for Integrative Genomics, University of Lausanne, Le Génopode, Lausanne, Switzerland
3 Lee Kong Chian School of Medicine, Nanyang Technological University, Academia, College Road, Singapore, Singapore
4 School of Biological Sciences, Nanyang Technological University, Nanyang Drive, Singapore, Singapore
5 Institute of Molecular and Cell Biology, Proteos, A*STAR, Singapore, Singapore
* Reprints
- Mots-clés : diabetic wound, epithelial tumours, keratinocytes, non-melanoma skin cancer, nuclear receptors, wound healing
- DOI : 10.1684/ejd.2014.2505
- Page(s) : 4-11
- Année de parution : 2015
Lipid signalling is important for maintaining healthy skin and its disruption is implicated in some skin diseases. The peroxisome proliferator-activated receptors (PPARs), which are members of the nuclear receptor superfamily, are key mediators of this signalling process. PPARs are transcription factors activated by lipophilic molecules that act as ligands. Importantly, these receptors link fluctuations in the levels and distribution of fatty acids, eicosanoids, and some phospholipids to changes [...]