European Journal of Dermatology


Mutations in the γ-secretase genes PSEN1, PSENEN, and NCSTN in a family with acne inversa Volume 28, numéro 3, May-June 2018


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1 The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
2 Department of Dermatology, People's Hospital of Zhengzhou, Zhengzhou 450003, China
3 Department of Plastic Surgery, Nanfang Hospital, the First Affiliated Hospital of Southern Medical University, Guangzhou 510515, China
4 Department of medicine, Henan Cancer Hospital, the Affiliated Hospital of Zhengzhou University, Zhengzhou 450003, China
a These authors contributed equally
b These authors are both corresponding authors

Acne inversa (AI) is a type of chronic, relapsing hidradenitis and an inflammatory disorder of the skin. It primarily involves the intertriginous skin and entails the recurrence of abscesses in the sinus tracts, fistula, and cicatrization, leading to disfigurement and disability. The aetiology of AI is unknown; there are several likely pathogenic factors, including genetics, immunity, sex hormones, mechanical stress, smoking, and obesity [1]. Genetic studies have led to the discovery of mutations [...]