European Journal of Dermatology


Local desensitization and progression of multiple fixed drug eruption Volume 28, numéro 3, May-June 2018


  • Figure 1
1 Department of Dermatology, Okayama City Hospital, Okayama, Japan
2 Department of Dermatology, Kawasaki Medical Center, Kawasaki Medical School, Okayama, Japan
3 Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
4 Department of Dermatology, Okamuraisshindo Hospital, Okayama, Japan

Fixed drug eruption (FDE) usually relapses at the same sites with each administration of the causative drug [1, 2]. However, there is a deviation from this characteristic sequence; certain sites are not involved with subsequent flare, while other sites are flared, creating a “wandering” appearance [3, 4]. Accumulating evidence indicates that FDE occurs following activation of skin-resident memory T cells (TRM) [1] and its amelioration is associated with the influx of regulatory T cells (Tregs) [5]. [...]