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European Journal of Dermatology

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Inhibition of MAPK signaling pathways enhances cell death induced by 5-Aminolevulinic acid-photodynamic therapy in skin squamous carcinoma cells Volume 26, numéro 2, March-April 2016

Illustrations


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Auteurs
1 Institute for Cancer Research,
School of Basic Medical Science,
Health science center of Xi’an Jiaotong University,
Xi’an,
P. R. China
2 Department of Dermatology,
3 Center of Laboratory Medicine,
General Hospital of Ningxia Medical University,
Yinchuan,
P. R. China
4 Department of Pathology,
Basic Medical School,
Ningxia Medical University,
Yinchuan,
P. R. China
5 Department of Pharmaceutical Sciences,
North Carolina Central University,
Durham,
NC,
USA
6 Department of Dermatology,
People's Hospital of Zhangdian District,
Zibo City,
Shandong province,
P. R. China
* Reprints

The incidence of skin cancer has increased worldwide [1, 2]. Finding an effective treatment for SCC is therefore of great clinical significance. Over the last thirty years, a procedure known as photodynamic therapy (PDT) has been developed and is showing some success in combating SCC [3]. PDT employs the use of a drug, the photosensitizer or photosensitizing agent, which is taken up by the patient's cells. The photosensitizer tends to accumulate and be retained longer in cancerous cells than in normal [...]