JLE

European Journal of Dermatology

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In situ localization of IFN-gamma-positive cells in psoriatic lesional epidermis Volume 12, numéro 1, January - February 2002

Auteurs
Department of Dermatology, Graduate School of Medical Sciences Kyushu University 3-1-1, Maidashi, Higashiku, J-812-8582 Fukuoka, Japan.
  • Page(s) : 20-3
  • Année de parution : 2002

Skin lesions of psoriasis are thought to be a result of immune response that is mediated by various cytokines [1]. Accumulated evidence from both in vivo and in vitro studies show that interferon-gamma (IFN-gamma) is a critical element in the induction of keratinocyte hyperproliferation in psoriasis [2-4]. Psoriasis is accompanied by an infiltration of activated T cells in the papillary dermis and the epidermis. The presence and potential [...]