Department of Dermatology, Johannes Gutenberg-University, Langenbeckstrasse 1, 55131 Mainz
- Mots-clés : Leishmania, dendritic cells, neutrophils, Th1/Th2, macrophages, mast cells
- DOI : 10.1684/ejd.2007.0122
- Page(s) : 115-22
- Année de parution : 2007
Millions of Leishmania major infections in humans are reported worldwide. In experimental infections, various phagocytes predominant in skin – neutrophils, macrophages (MΦ) and dendritic cells (DC) – play very distinct roles for the hosts’ immune response against L. major infection and they are sequentially engaged via different pathogen recognition receptors as cutaneous leishmaniasis evolves. In the initial “silent” phase without clinically apparent inflammation, L. major promastigotes are primarily phagocytosed by resident MΦ via CR3. Upon activation of cutaneous mast cells, inflammatory neutrophils and monocytes are recruited to the skin coincident with the development of a nodular plaque. Later on, in established infections, DC-, B cell- and Tcell-dependent immunity becomes critically important for lesion resolution. Antibody-mediated uptake of L. major by DC leads to IL-12 production and priming of Th1/Tc1 cells, both of which are required for efficient parasite killing by lesional MΦ. Finally, Fc receptor-mediated uptake of L. major by MΦ induces counter-regulatory IL-10 production leading to parasite persistence. Thus, the balance between CR3 – and FcγR-triggered anti- and proinflammatory mechanisms involving MΦ and DC is critical for disease outcome. This review highlights the importance of the various phagocytes for the development of anti-Leishmania immunity.