European Journal of Dermatology


Immunocytochemical demonstration of reduced Cu,Zn-superoxide dismutase levels following topical application of dithranol and sodium lauryl sulphate: an indication of the role of oxidative stress in acute irritant contact dermatitis Volume 8, numéro 1, January - February 1998

Department of Dermatology, Amersham Hospital, Whielden Street, Amersham, Bucks, HP7 0JD, UK.

Oxidative stress is a condition of pro-oxidant/ antioxidant disequilibrium, in which the generation of potentially harmful reactive oxygen species (ROS) exceeds the ability of the tissue's antioxidant defence mechanisms to quench them. Damage to cell membranes by way of lipid peroxidation, and damage to DNA, sulphur-containing enzymes and proteins, and carbohydrates are amongst the major resultant effects [1, 2]. A number [...]