JLE

European Journal of Dermatology

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Glucocorticoid receptors GRα and GRβ are expressed in inflammatory dermatoses Volume 26, numéro 1, January-February 2016

Illustrations


  • Figure 1

  • Figure 2

  • Figure 3

Tableaux

Auteurs
1 PEDEGO Research Center,
Oulu Center for Cell-Matrix Research,
Department of Dermatology and Medical Research Center Oulu,
Oulu University Hospital and University of Oulu,
FIN-90220, Oulu, Finland
2 Department of Pathology and Medical Research Center Oulu,
Oulu University Hospital and University of Oulu,
FIN-90220, Oulu, Finland
3 Department of Pathology,
Oulu University Hospital and University of Oulu,
FIN-90220, Oulu, Finland
* Reprints

Glucocorticoids (GC) are the most commonly used anti-inflammatory and immunosuppressive drugs in inflammatory dermatoses. The actions of GCs are mediated by the intracellular glucocorticoid receptor (GR). GRs belong to a superfamily of nuclear hormone receptors that transduce hormonal signals to the nucleus where they act at the level of gene transcription [1]. The human GR exists in several splicing variants of which glucocorticoid receptors alpha (GRα) and beta (GRβ) are the most important [2-4]. [...]