European Journal of Dermatology
MENUGlucocorticoid receptors GRα and GRβ are expressed in inflammatory dermatoses Volume 26, numéro 1, January-February 2016
Auteurs
1 PEDEGO Research Center,
Oulu Center for Cell-Matrix Research,
Department of Dermatology and Medical Research Center Oulu,
Oulu University Hospital and University of Oulu,
FIN-90220, Oulu, Finland
Oulu Center for Cell-Matrix Research,
Department of Dermatology and Medical Research Center Oulu,
Oulu University Hospital and University of Oulu,
FIN-90220, Oulu, Finland
2 Department of Pathology and Medical Research Center Oulu,
Oulu University Hospital and University of Oulu,
FIN-90220, Oulu, Finland
Oulu University Hospital and University of Oulu,
FIN-90220, Oulu, Finland
3 Department of Pathology,
Oulu University Hospital and University of Oulu,
FIN-90220, Oulu, Finland
Oulu University Hospital and University of Oulu,
FIN-90220, Oulu, Finland
* Reprints
- Mots-clés : atopic dermatitis, glucocorticoid receptor alpha, glucocorticoid receptor beta, glucocorticoid resistance, inflammatory dermatoses, neutrophil
- DOI : 10.1684/ejd.2015.2691
- Page(s) : 21-7
- Année de parution : 2016
Glucocorticoids (GC) are the most commonly used anti-inflammatory and immunosuppressive drugs in inflammatory dermatoses. The actions of GCs are mediated by the intracellular glucocorticoid receptor (GR). GRs belong to a superfamily of nuclear hormone receptors that transduce hormonal signals to the nucleus where they act at the level of gene transcription [1]. The human GR exists in several splicing variants of which glucocorticoid receptors alpha (GRα) and beta (GRβ) are the most important [2-4]. [...]