John Libbey Eurotext

European Journal of Dermatology

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Genetic background and therapeutic response in generalized pustular psoriasis patients treated with granulocyte and monocyte adsorption apheresis Volume 28, numéro 1, January-February 2018

Tableaux

Auteurs
1 Department of Paediatrics, Gifu University Graduate School of Medicine, Gifu, Japan
2 Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan
3 Department of Geriatric and Environmental Dermatology, Nagoya City, University Graduate School of Medical Sciences, Aichi, Japan
4 Department of Dermatology, Tokyo Medical University, Tokyo, Japan
5 Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
6 Department of Dermatology, St. Luke's International Hospital, Tokyo, Japan
7 Department of Dermatology, Asahikawa Medical University, Hokkaido, Japan
8 Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
9 Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan

Psoriasis is a chronic inflammatory dermatosis with several features of other organs. In psoriasis, several inflammatory cell types infiltrate the dermis, including T cells, dendritic cells, and neutrophils, probably in response to excessive innate and acquired immune responses. Recently, the genetic aetiology of psoriasis has been rigorously analysed. Fifteen psoriasis susceptibility loci (PSORS1-15) have been identified. Mutations of the IL36RN, CARD14 and AP1S3 genes underlie monogenic auto-inflammatory [...]