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European Journal of Dermatology

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Fate of MHC class II molecules in human dendritic cells Volume 9, numéro 1, January - February 1999

Auteurs
CJF INSERM 94-03, Laboratoire d’Histocompatibilité, ETS de Strasbourg, 67065 Strasbourg, France.
  • Page(s) : 7-12
  • Année de parution : 1999

MHC class II molecules expressed at the surface of antigen presenting cells mediate the presentation of peptides derived from exogenous antigens to CD4+ T lymphocytes. These molecules are assembled in the endoplasmic reticulum as nonamers composed of three alphaß dimers associated with one trimer of invariant chains. The invariant chains, chaperone molecules necessary for the correct folding of class II molecules in the endoplasmic [...]