European Journal of Dermatology
MENUFate of MHC class II molecules in human dendritic cells Volume 9, numéro 1, January - February 1999
Illustrations
Daniel HANAU, Cédric SAUDRAIS, Hélène HAEGEL-KRONENBERGER, Alain BOHBOT, Henri DE LA SALLE, Jean SALAMERO
CJF INSERM 94-03, Laboratoire d’Histocompatibilité, ETS de Strasbourg, 67065 Strasbourg, France.
- Page(s) : 7-12
- Année de parution : 1999
MHC class II molecules expressed at the surface of antigen presenting cells mediate the presentation of peptides derived from exogenous antigens to CD4+ T lymphocytes. These molecules are assembled in the endoplasmic reticulum as nonamers composed of three alphaß dimers associated with one trimer of invariant chains. The invariant chains, chaperone molecules necessary for the correct folding of class II molecules in the endoplasmic [...]