John Libbey Eurotext

European Journal of Dermatology


Expression of keratin 1, keratin 10, desmoglein 1 and desmocollin 1 in the epidermis: possible downregulation by interleukin-4 and interleukin-13 in atopic dermatitis Volume 27, numéro 3, May-June 2017


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1 Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan
2 Department of Microbiology and Immunology, Tokyo Women's Medical University, Tokyo, Japan
* Reprints
  • Mots-clés : adhesion molecule, atopic dermatitis, interleukin-4, interleukin-13, stratum spinosum, structural protein
  • DOI : 10.1684/ejd.2017.2985
  • Page(s) : 247-53
  • Année de parution : 2017


In the pathogenesis of atopic dermatitis (AD), skin barrier dysfunction and T-helper (Th) type 2 immune reactions play important roles. Alterations in the stratum spinosum of AD have not been studied in much detail.