JLE

European Journal of Dermatology

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Expression of cathepsins in dermal fibrous tumors: an immunohistochemical study Volume 8, numéro 2, March 1998

Auteurs
Department of Dermatology and Allergy, Biederstein, Technical University Munich, Biedersteinstraße 29, 80802 Munich, Germany.
  • Page(s) : 86-9
  • Année de parution : 1998

Cathepsins are lysosomal proteinases which are expressed in many normal cells showing an increased intracellular protein catabolism [1, 4]. Their expression can be regulated by endogenous inhibitors, for example cystatins [5]. Their synthesis and secretion is stimulated by oncogenic transformation, tumor promoters and growth factors [6, 7]. A major feature of malignant tumors is their ability to invade normal tissues, to colonize [...]