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European Journal of Dermatology

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Effect of activated human mast cells and mast cell-derived mediators on proliferation, type I collagen production and glycosaminoglycans synthesis by human dermal fibroblasts Volume 12, numéro 4, July - August 2002

Auteurs
Dept. Cell Biology (Grinnell Lab), UT Southwestern Med. Ctr. 5323 Harry Hines Blvd. Dallas, TX 75390-9039 USA
  • Page(s) : 340-6
  • Année de parution : 2002

Mast cells are known to play a central role in IgE-mediated allergic reactions, including both immediate and late-phase constituents. Recent studies suggest that mast cells appear in other biological reactions in which IgE is not essential. For example, accumulated mast cells are frequently observed at sites of fibrosis such as keloids, healing wounds or the early stage of systemic sclerosis (SSc) [1-5]. The speculation that mast cells [...]