European Journal of Dermatology
MENUDifferential effects of two local anaesthetics on viability of skin keratinocytes in vitro Volume 28, numéro 3, May-June 2018
Illustrations
1 Laboratory of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Greece
2 Department of Nursing, Epirus Institute of Technology (T.E.I. of Epirus), Ioannina, Greece
3 Director of Pain Centre of Athens, Medical Centre, Athens, Greece
4 Department of Skin and Venereal Diseases, Faculty of Medicine, School of Health Sciences, University of Ioannina, Greece
- DOI : 10.1684/ejd.2018.3275
- Page(s) : 409-10
- Année de parution : 2018
Levobupivacaine (LEV) and ropivacaine (ROP) are used widely as local anaesthetics in clinical practice due to their limited side effects, significant sensory/motor separation, and long duration of action [1-3]. However, both substances have been incriminated to reduce viability of chondrocytes in vitro and trigger apoptosis in corneal endothelial cells in vivo[4, 5]. Moreover, in vitro, LEV has been shown to exert antiproliferative activity on human cancer cells with variable bioenergetic profile [...]