European Journal of Dermatology


Coagulation factor XIII, endothelial damage and systemic sclerosis Volume 10, numéro 1, January - February 2000

Institute of Dermatological Sciences, University of Milan, IRCCS Ospedale Maggiore, Milan, Italy.
  • Page(s) : 14-7
  • Année de parution : 2000

Systemic sclerosis (SSc) is a multisystem connective tissue disorder of autoimmune origin, characterized by alteration of the microvasculature and deposition of collagen. Various drugs are used in SSc, including antiinflammatory drugs, immunosuppressive agents, immunomodifiers and drugs that interfere with collagen production. Among these latter, there is coagulation Factor XIII (F XIII), first used by Thivolet and coworkers [1]. F XIII, other [...]