European Journal of Dermatology
MENUCharacteristics of peripheral blood CD4+CD25+ regulatory T cells and related cytokines in severe atopic dermatitis Volume 26, numéro 3, May-June 2016
Auteurs
1 Department of Dermatology,
2 Department of Clinical Laboratory,
the 2nd Affiliated Hospital of Dalian Medical University
No.467 Zhongshan Road
Dalian, 116027, Liaoning Province
P R. China
the 2nd Affiliated Hospital of Dalian Medical University
No.467 Zhongshan Road
Dalian, 116027, Liaoning Province
P R. China
* Reprints
a Authors contributed equally.
- Mots-clés : atopic dermatitis, regulatory T cells, effector T cells
- DOI : 10.1684/ejd.2015.2709
- Page(s) : 240-6
- Année de parution : 2016
Many studies have supported that Regulatory T cell (Treg) activation may alleviate inflammation in allergic reactions [1, 2]. CD4+CD25+Tregs account for 5-10% of peripheral CD4+T cells in humans [3]. Tregs play a crucial role in self-tolerance, controlling autoimmune diseases and chronic infections by suppressing the activation, proliferation and function of Teffs. Tregs function via the cell surface molecule cytotoxic T-lymphocyte antigen 4 (CTLA-4, also known as CD152), as well as secreting inhibitory [...]