JLE

European Journal of Dermatology

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Bone involvement in two cases of thoracic primary cutaneous diffuse large B-cell lymphoma, leg type Volume 21, numéro 5, September-October 2011

Auteurs
Department of Dermatology, Tenon Hospital, 4 rue de la Chine 75020 Paris University Pierre et Marie Curie, France, Department of Dermatology, CHU de Bordeaux, Haut-Lévêque Hospital, 33604 Pessac, France, Departments of Hematology, Radiology, Pitié-Salpêtrière Hospital, 75013 Paris, France, Department of Pathology, Haut-Lévêque Hospital, CHU de Bordeaux, 33604 Pessac France, Department of Pathology, Pitié-Salpêtrière Hospital, 75013 Paris University Pierre et Marie Curie, France

Primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL-LT), is defined by a predominance of confluent sheets of centroblasts and immunoblasts, which strongly express Bcl-2 protein. This cutaneous lymphoma is mainly characterized by the development of skin lesions on the lower leg. Other localizations are possible (namely non-leg PCLBCL-LT) and usually affect younger patients. PCLBCL–LT is distinguished from the two other subtypes of primary cutaneous B-cell lymphomas by its immunohistopathological features, its aggressive clinical behaviour with a worse prognosis linked to skin recurrences, but also secondary extracutaneous spread. Bone involvement underlying skin lesions has been reported in few series and cases reports during PCLBCL-LT. We describe here two aggressive cases of PCLBCL-LT with high burden and infiltrative thoracic tumours, with localized bone involvement.