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European Journal of Dermatology

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Anticonvulsant hypersensitivity syndrome with fatal outcome Volume 12, numéro 5, September - October 2002

Auteur
Department of Dermatology, Hospital Ramón y Cajal, Carretera de Colmenar, Kilometro 9,100, 28034 Madrid, Spain.
  • Page(s) : 503-5
  • Année de parution : 2002

Anticonvulsant hypersensitivity syndrome is a disease characterized by multisystemic involvement, fever, lymphadenopathy, mucocutaneous rash, hypertransaminasemia and peripheral eosinophilia. This rare syndrome seems to be related to arene oxide metabolites of aromatic anticonvulsants (phenytoin, phenobarbital and carbamazepine). Anticonvulsant hypersensitivity seems to be much more aggressive in patients undergoing concomitant radiotherapy. [...]