John Libbey Eurotext

European Journal of Dermatology

A hyperkeratotic linear lesion in a girl with kid syndrome. A further example of early allelic loss? Volume 9, numéro 2, March 1999

Auteurs
Center for Inherited Cutaneous Diseases, Institute of Dermatological Science, IRCCS Ospedale Maggiore, via Pace 9, Milan, Italy.
  • Page(s) : 142-3
  • Année de parution : 1999

Sir, In rare instances, patients with autosomal dominant skin disorders such as actinic porokeratosis and Darier disease, show linear areas of markedly more severe involvement with respect to the surrounding skin. It has been hypothesized that this phenomenon is due to an early loss of heterozygosity. In a heterozygous embryo, a further mutation occurring early in embryonic life may lead to the formation of a clone of homozygous [...]