John Libbey Eurotext

European Journal of Dermatology


A cream based on Aquaphilus dolomiae extracts alleviates non-histaminergic pruritus in humans Volume 27, numéro 3, May-June 2017


  • Figure 1
1 Department of Medicine,
Section of Dermatology,
University of Verona,
2 Laboratoires Dermatologiques Avene,

Itch is a symptom of many skin diseases. At least two pathways of itch have been described: a histaminergic and a non-histaminergic pathway. The latter is activated by cowhage, a tropical plant with spicules that, upon skin contact, release mucunain, a cysteine protease serving as a ligand for the protease-activated receptor 2 (PAR-2) [1]. In humans, PAR-2, expressed by mechanically-sensitive C fibres and keratinocytes, is involved in the development of inflammation and itch in atopic dermatitis [...]