John Libbey Eurotext

European Journal of Dermatology


A case of severe pityriasis rubra pilaris with a dramatic response to apremilast Volume 28, numéro 1, January-February 2018


  • Figure 1
1 Department of Dermatology,
2 Department of Pathology,
University Clermont-Auvergne,
CHU Clermont-Ferrand,
Clermont-Ferrand, France

Pityriasis rubra pilaris (PRP) is characterized by hyperkeratotic follicular papules and widespread erythema with areas of spared skin, which may evolve towards erythroderma with palmoplantar keratoderma. Whereas the disease may spontaneously heal, many patients experience long periods during which the condition is disabling. Treatments used for psoriasis are given with variable results. Apremilast, a phosphodiesterase 4 (PDE4) inhibitor, which increases cyclic adenosine monophosphate levels leading [...]