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Up-regulation of mucin secretion in HT29-MTX cells by the pro-inflammatory cytokines tumor necrosis factor-a and interleukin-6. Volume 12, numéro 1, March 2001

Auteurs
Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
  • Page(s) : 119-25
  • Année de parution : 2001

INTRODUCTION IL-6 and TNF-alpha are multifunctional cytokines involved in the regulation of the immune response and inflammation, and have been found to regulate the local and systematic reactions accompanying different types of inflammation [1-3]. Otitis media with effusion (OME) is a disease characterized by an increase in goblet cells and submucosal glands in middle ear cleft mucosa. These cellular changes are accompanied by [...]