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Tyrosine kinase is essential for the constitutive expression of type I interleukin-1 receptor in human fibroblast cells. Volume 10, numéro 2, June 1999

Auteurs
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Mizuho, Nagoya, 467-8603 Japan.
  • Page(s) : 237-46
  • Année de parution : 1999

INTRODUCTION Interleukin-1 (IL-1) is a group of monocyte-derived peptides that play a pivotal role in regulating the host response to infection and injury. Two related forms of IL-1 (alpha and ß) exhibit 26% identity at the amino acid sequence level [1]. IL-1 mediates many features of inflammation such as fever, the acute phase response, leukocyte accumulation, and bone resorption [2] as well as connective tissue degradation [...]