John Libbey Eurotext

European Cytokine Network


The importance of shedding of membrane proteins for cytokine biology. Volume 11, numéro 1, March 2000

I. Medical Clinic, Section Pathophysiology, Johannes Gutenberg-Universität Mainz, Obere Zahlbacher Strasse 63, D-55101 Mainz, Germany;
  • Mots-clés : ADAM family, cytokine, cytokine receptor, shedding, TACE.
  • Page(s) : 27-38
  • Année de parution : 2000

INTRODUCTION Many cellular membrane proteins are subjected to limited proteolysis giving rise to soluble forms consisting of the entire extracellular domains of the proteins. This process is referred to as shedding. The field has been reviewed in ref. [1-3]. Importantly, soluble forms of receptors for growth factors and cytokines retain their ability to bind their ligands. Moreover, many cytokines are synthesized as transmembrane precursor [...]