I. Medical Clinic, Section Pathophysiology, Johannes Gutenberg-Universität Mainz, Obere Zahlbacher Strasse 63, D-55101 Mainz, Germany; email@example.com
- Mots-clés : ADAM family, cytokine, cytokine receptor, shedding, TACE.
- Page(s) : 27-38
- Année de parution : 2000
Many cellular membrane proteins are subjected to limited proteolysis
giving rise to soluble forms consisting of the entire extracellular domains
of the proteins. This process is referred to as shedding. The field has
been reviewed in ref. [1-3]. Importantly, soluble forms of receptors for
growth factors and cytokines retain their ability to bind their ligands.
Moreover, many cytokines are synthesized as transmembrane precursor [...]