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The H2b haplotype modifies the production of pro-inflammatory cytokines: implications for immunopathology Volume 11, numéro 4, December 2000

Auteurs
Department of Clinical Immunology and Biochemical Genetics. GPO Box X2213, Royal Perth Hospital, Wellington Street Perth, W.A., 6000 Australia.
  • Page(s) : 640-6
  • Année de parution : 2000

INTRODUCTION Human major histocompatibility complex (MHC) genes are the most potent genetic determinants of susceptibility to many autoimmune or immunopathological conditions. Whilst this is frequently attributed to human leukocyte antigen (HLA) class II alleles [1, 2], there is mounting evidence that the central MHC encodes regulatory molecules able to affect immune responses in a non-antigen specific manner [3]. Humans and mice have central [...]