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Regulation of Staphylococcus aureus-mediated activation of interleukin-18 in peripheral blood mononuclear cells Volume 12, numéro 4, December 2001

Auteurs
University Hospital Mannheim, Theodor-Kutzer-Ufer, D-68167 Mannheim, Germany.
  • Page(s) : 631-8
  • Année de parution : 2002

INTRODUCTION Polymorphonuclear granulocytes and monocytes drive the host's initial cellular response to an invader. Cytokines released by monocytes secondarily activate non-specific natural killer cells as well as T and B cells. While natural killer cells mount a fast and strong immune response during acute infection, T and B cells are crucial in the chronic phase. Among the monocyte-derived cytokines are IL-12 and the recently cloned IL-18 [...]