European Cytokine Network
MENURegression of Morris hepatoma in response to intralesional treatment with tumor necrosis factor muteins Volume 8, numéro 3, September 1997
Illustrations
- Mots-clés : TNF-alpha, mutein, antitumor effects, intralesional treatment, Morris hepatoma 5123, rats.
- Page(s) : 259-63
- Année de parution : 1997
INTRODUCTION Tumor necrosis factor alpha (TNF-alpha), a physiologically important cytokine produced by activated macrophages, plays multiple roles as a mediator of inflammation and the immune response [1]. TNF-alpha has potentially synergistic antitumor effects, such as direct cytotoxicity against tumor cells, indirect cytotoxicity by activating a host immune antitumor response and selective impairment of the microcirculation [...]