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European Cytokine Network

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Regression of Morris hepatoma in response to intralesional treatment with tumor necrosis factor muteins Volume 8, numéro 3, September 1997

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INTRODUCTION Tumor necrosis factor alpha (TNF-alpha), a physiologically important cytokine produced by activated macrophages, plays multiple roles as a mediator of inflammation and the immune response [1]. TNF-alpha has potentially synergistic antitumor effects, such as direct cytotoxicity against tumor cells, indirect cytotoxicity by activating a host immune antitumor response and selective impairment of the microcirculation [...]