European Cytokine Network
MENUNeutrophils and monocytes from subjects with the Mediterranean G6PD variant: effect of Plasmodium falciparum hemozoin on G6PD activity, oxidative burst and cytokine production. Volume 9, numéro 3, September 1998
Illustrations
Sektion Humanparasitologie, Institut für Tropenmedizin, Universität Tübingen, Germany
- Mots-clés : oxidative burst, TNF, IL-10, IL-12, malaria, hemozoin.
- Page(s) : 239-46
- Année de parution : 1998
INTRODUCTION Glucose 6-phosphate dehydrogenase (G6PD), the first and rate limiting enzyme of the pentose phosphate pathway, is a housekeeping enzyme and as such is highly conserved [1, 2]. As shown by targeted gene disruption, G6PD seems to be essential for defense against oxidative stress in mammalian cells by providing reduced nicotinamide adenine dinucleotide phosphate (NADPH) to reduce oxidized glutathione [3]. In neutrophils [...]