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Neutrophils and monocytes from subjects with the Mediterranean G6PD variant: effect of Plasmodium falciparum hemozoin on G6PD activity, oxidative burst and cytokine production. Volume 9, numéro 3, September 1998

Auteurs
Sektion Humanparasitologie, Institut für Tropenmedizin, Universität Tübingen, Germany

INTRODUCTION Glucose 6-phosphate dehydrogenase (G6PD), the first and rate limiting enzyme of the pentose phosphate pathway, is a housekeeping enzyme and as such is highly conserved [1, 2]. As shown by targeted gene disruption, G6PD seems to be essential for defense against oxidative stress in mammalian cells by providing reduced nicotinamide adenine dinucleotide phosphate (NADPH) to reduce oxidized glutathione [3]. In neutrophils [...]