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European Cytokine Network

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Neutrophil F-actin and myosin but not microtubules functionally regulate transepithelial migration induced by interleukin 8 across a cultured intestinal epithelial monolayer. Volume 10, numéro 2, June 1999

Auteurs
INSERM U. 364, Faculté de Médecine de Nice, avenue de Vallombrose, 06107 Nice Cedex 01, France.
  • Page(s) : 227-36
  • Année de parution : 1999

INTRODUCTION At the onset of acute infection, circulating polymorphonuclear leukocytes (PMN) are stimulated to migrate from the bloodstream by chemoattractant peptides such as f-met-leu-phe (f-MLP) secreted by bacterial pathogens, or by cytokines such as interleukin-8 (IL-8) secreted by epithelial cells. Such stimulation of PMN results in reversible adhesion to endothelial cells during diapedesis followed by transmigration [...]