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Modulation of LPS-, PHA- and M. tuberculosis-mediated cytokine production by pentoxifylline and thalidomide Volume 11, numéro 4, December 2000

Auteurs
University Medical Centre St Radboud, Department of Internal Medicine, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
  • Page(s) : 574-9
  • Année de parution : 2000

INTRODUCTION Tumour necrosis factor-alpha (TNF-alpha) is essential to host immunity, but excessive production of TNF-alpha and other proinflammatory cytokines may have deleterious effects in acute and chronic inflammatory conditions. TNF-alpha activity has been implicated as a central mediator in the pathogenesis of a wide range of human diseases including autoimmune disorders, cancer cachexia and endotoxic shock [1]. In human tuberculosis, [...]