JLE

European Cytokine Network

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Leukemia inhibitory factor involvement in human ulcerative colitis and its potential role in malignant course. Volume 9, numéro 4, December 1998

Auteurs
Service d’Hépatogastroentérologie, Hôpital Cochin, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. Tel: (+33) 1.42.34.15.38, Fax: (+33) 1.42.34.50.09, e-mail: stanislas.chaussade@cch.ap-hop-paris.fr
  • Page(s) : 607-12
  • Année de parution : 1999

INTRODUCTION LIF, a member of the hematopoietic family of growth factors, is a pleitropic cytokine initially identified by its growth-promoting activity on the murine IL-3-dependent DA-1 cell line [1]. Since, several other activities have been ascribed to LIF, mainly: proinflammatory actions, tumorogenesis and embryonic development. LIF has been detected in normal as well as in tumor cells. In normal adult mouse many tissues [...]