JLE

European Cytokine Network

MENU

Interleukin-6 receptor signaling. I. gp80 and gp130 receptor interaction in the absence of interleukin-6. Volume 10, numéro 1, March 1999

Auteurs
INSERM U. 475, 99, rue Puech-Villa, 34197 Montpellier, Cedex 05 France.
  • Page(s) : 43-8
  • Année de parution : 1999

INTRODUCTION IL-6 is a pleiotropic cytokine that acts on various target cells [1]. Its receptor is composed of a ligand binding 80 kDa glycoprotein (IL-6R) [2] and a signal transducing 130 kDa glycoprotein (gp130) [3], both of which belong to the haematopoietin receptor superfamily [4]. IL-6 signaling results from its low affinity contact with the IL-6R chain, leading to the association of the complex with the gp130 subunit [...]