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European Cytokine Network

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Interleukin-13 effects on activated monocytes lead to novel cytokine secretion profiles intermediate between those induced by interleukin-10 and by interferon-Adrian Volume 8, numéro 2, June 1997

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INTRODUCTION IL-13 is the most recently discovered of the anti-inflammatory TH2 cytokine trio (IL-4, IL-10, IL-13). It is produced by type 2 lymphocytes in the mouse [1], and is present in the "type 2 lymphokine gene cluster" on the long arm of human chromosome 5, where it is closely linked to the IL-4 gene [2]. Since the original description of its anti-inflammatory activity on monokine production [3], this aspect of IL-13 [...]