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Interleukin-10 in combination with interferon-gamma and tumor necrosis factor-alpha enhances in vitro production of nitric oxide by murine resident paritoneal macrophage. Volume 10, numéro 1, March 1999

Auteur
Institute of Pharmacology, Academy of Sciences of the Czech Republic, Vídexnská 1083, 142 20 Prague 4, Czech Republic.
  • Page(s) : 25-32
  • Année de parution : 1999

INTRODUCTION Nitric oxide (NO) is derived from the oxidation of the terminal guanidine nitrogen atom of L-arginine by the NADPH-dependent enzyme NO synthase (NOS). There are three isoforms of this enzyme currently recognized [1]. The high-output NO production, effectuated by the inducible Ca2+-independent NOS (iNOS) encoded mainly in macrophages, is only expressed after activation of cells by LPS, or IFN-gamma [2-4]. Other [...]