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Increased expression of interleukin-8 and aminopeptidase N by cell-cell contact: interleukin-8 is resistant to degradation by aminopeptidase N/CD13. Volume 12, numéro 2, June 2001

Auteurs
University, Institute of Medical Immunology, Magdeburger Straße 2, D-06097 Halle, Germany.
  • Page(s) : 316-24
  • Année de parution : 2001

INTRODUCTION APN/CD13 (EC 3.4.11.2) is a membrane-bound enzyme of almost ubiquitous occurrence (for reviews see 1, 2, 3) that for a long time has been considered as a myeloid marker on haematopoietic cells. Our group became interested in aminopeptidase N (APN)/CD13 expression on lymphocytes when we observed that lymphocytes from pannus tissue or synovial fluid of rheumatoid arthritis (RA) joints are strongly APN/CD13 positive, quite in [...]