Department of Neurosciences, Division of Neurology, Geneva University Hospitals, Geneva, Switzerland
Department of Diagnostic Division of Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland
Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Department of Medicine, Division of Immunology and Allergy, Geneva University Hospitals, Geneva, Switzerland
This pilot study was designed to compare the levels of interleukin-8 (IL-8), a pro-inflammatory chemokine, in the cerebrospinal fluid (CSF) of patients with Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), non-inflammatory polyneuropathy (PNP), and other non-inflammatory neurological diseases (functional syndrome or migraine). The results show elevated CSF IL-8 levels in GBS compared to the other groups (p < 0.05). IL-8 could be considered a potential biomarker to differentiate GBS from CIDP. This distinction could be relevant in terms of therapeutic decisions and functional prognosis.