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Glucose potentiates interleukin-1b-induced p38 mitogen-activated protein (MAP) pancreatic islets of Langerhans. Volume 12, numéro 2, June 2001

Auteurs
Steno Diabetes Center, 2 Niels Steensens vej, DK-2820 Gentofte, Denmark.
  • Page(s) : 331-9
  • Année de parution : 2001

INTRODUCTION The cytokine IL-1beta is cytotoxic to rat pancreatic beta-cells, and together with tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) also to human beta-cells in vitro [1], and has been implicated in the pathogenesis of insulin-dependent diabetes mellitus. IL-1beta causes expression of iNOS and production of NO. NO may be a mediator of the cytotoxic effect of IL-1beta in rat islets and beta-cell lines [...]