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European Cytokine Network

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Enhancement by IL-12 of the cytolytic T lymphocyte (CTL) response of mice immunized with tumor-specific peptides in an adjuvant containing QS21 and MPL. Volume 10, numéro 2, June 1999

Auteurs
Ludwig Institute for Cancer Research, Brussels Branch, 74 Avenue Hippocrate-UCL 74.59, B-1200 Brussels, Belgium.
  • Page(s) : 181-90
  • Année de parution : 1999

INTRODUCTION Several antigens recognized by autologous cytolytic T lymphocytes (CTL) have been well characterized in a large variety of human tumors [1]. Some of these antigens, such as those encoded by MAGE genes, result from the activation of genes that are completely silent in normal tissues. They are strictly tumor-specific and are shared by many tumors of various histological origins. A second group of human tumor antigens [...]