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Direct effects of tumor necrosis factor alpha (TNF-alpha) on murine skeletal muscle cell lines. Bimodal effects on protein metabolism Volume 12, numéro 3, September 2001

Auteurs
Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028-Barcelona, Spain.
  • Page(s) : 399-410
  • Année de parution : 2001

INTRODUCTION Tumour necrosis factor-alpha (TNF-alpha) is a pleiotropic cytokine which exerts a variety of effects, such as growth promotion or inhibition, cytotoxicity, angiogenesis, inflammation and immunomodulation. Although TNF-alpha is mainly produced by immune cells in response to infection, tumour growth and other invasive stimuli, many cell types have been reported to produce and release TNF-alpha [1]. TNF-alpha is synthesized as [...]