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Clinical and cytokine profile evaluation in Northeast Brazilian psoriasis plaque-type patients Volume 27, numéro 1, March 2016

Illustrations


  • Figure 1

Tableaux

Auteurs
1 Laboratory of Immunomodulation and Novel Therapeutic Approaches (LINAT), Research Center for Therapeutic Innovation Suely Galdino (NUPIT-SG), UFPE, Recife, Brazil
2 Clinics Hospital, Federal University of Pernambuco (UFPE), Recife, Brazil
* Correspondence: M.G.R. Pitta, Universidade Federal de Pernambuco (UFPE), Centro de Ciências Biológicas, Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino (Nupit SG), Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife – PE, 50670-901, Brazil

Objective and Design

Psoriasis is a common, enigmatic, and recurrent disease. The precise etiology and pathogenesis of psoriasis are still unclear. Psoriasis has been treated as an inflammatory disorder related to an underlying Th1/Th17-dominated immune response. Interleukins are involved in the development of psoriasis lesions through Th-17-associated inflammation. Th1 and Th17 cytokines are found in skin lesions and in the peripheral blood of psoriasis patients. We sought to analyze serum levels of IL-1-β, IL-8, IL-9, IL-27, IL-29, IL-35, IFN-γ, TNF and TGF-β in patients with psoriasis and healthy control volunteers.