European Cytokine Network
MENUCINC-1 mediates the sympathetic component of inflammatory mechanical hypersensitivitiy in rats Volume 13, numéro 4, December 2002
Illustrations
Berenice B Lorenzetti, Fabiane H Veiga, Claudio A Canetti, Stephen Poole, Fernando Q Cunha, Sergio H Ferreira
Department of Pharmacology, Faculty of Medicine of Ribeir‹o Preto, University of S‹o Paulo, Avenida Bandeirantes, 3900, 14049-900- Ribeir‹o Preto, S‹o Paulo, Brazil
- Page(s) : 456-61
- Année de parution : 2003
Introduction Sensitisation of the pain receptor is the common denominator of inflammatory pain. This functional up-regulation of pain receptors is referred to as hyperalgesia [1]. Products of the arachidonic acid/cyclooxygenase pathway, e.g. prostaglandin (PG), and also the sympathomimetic amines are hyperalgesic mediators that directly sensitise the nociceptor [for review see 2]. The capacity of the PGE2 and PGI2 to sensitise the primary [...]