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CINC-1 mediates the sympathetic component of inflammatory mechanical hypersensitivitiy in rats Volume 13, numéro 4, December 2002

Auteurs
Department of Pharmacology, Faculty of Medicine of Ribeir‹o Preto, University of S‹o Paulo, Avenida Bandeirantes, 3900, 14049-900- Ribeir‹o Preto, S‹o Paulo, Brazil
  • Page(s) : 456-61
  • Année de parution : 2003

Introduction Sensitisation of the pain receptor is the common denominator of inflammatory pain. This functional up-regulation of pain receptors is referred to as hyperalgesia [1]. Products of the arachidonic acid/cyclooxygenase pathway, e.g. prostaglandin (PG), and also the sympathomimetic amines are hyperalgesic mediators that directly sensitise the nociceptor [for review see 2]. The capacity of the PGE2 and PGI2 to sensitise the primary [...]