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Adenoviral supply of active transforming growth factor-beta1 (TGF-beta1) did not prevent lethality in transforming growth factor-beta1-knockout embryos Volume 12, numéro 4, December 2001

Auteurs
INSERM U. 362, Institut Gustave-Roussy, PR1, 39, rue Camille-Desmoulins, 94805 Villejuif, France
  • Page(s) : 561-7
  • Année de parution : 2002

INTRODUCTION Transforming growth factor-beta1 (TGF-beta1) is a ubiquitous cytokine belonging to a large family of structurally-related polypeptides involved in many cellular processes [1]. In the adult, TGF-beta1 is essentially a molecule that negatively regulates immune and inflammatory responses by inhibiting the proliferation of hematopoietic cells (for review see [2]). This function has been definitively demonstrated by lethality in [...]