John Libbey Eurotext

European Cytokine Network


A short course of oral aspirin increases IL-18-induced interferon-g production in whole blood cultures Volume 11, numéro 3, September 2000

Division of Infectious Diseases, B168, University of Colorado Health Sciences Center, 4200 East Ninth Ave., Denver, CO 80262, USA
  • Page(s) : 379-82
  • Année de parution : 2000

INTRODUCTION Aspirin is the best known anti-inflammatory drug, acting to inhibit cyclooxygenase, leading to subsequent reduction in prostaglandin (PG) synthesis [1]. PG, especially PGE2, stimulate adenylcyclase, and cAMP inhibit the synthesis of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), two cytokines which contribute to inflammation [2]. Most studies investigating the effects of inhibitors of PG synthesis [...]