John Libbey Eurotext

European Cytokine Network

A short course of oral aspirin increases IL-18-induced interferon-g production in whole blood cultures Volume 11, numéro 3, September 2000

Auteurs
Division of Infectious Diseases, B168, University of Colorado Health Sciences Center, 4200 East Ninth Ave., Denver, CO 80262, USA
  • Page(s) : 379-82
  • Année de parution : 2000

INTRODUCTION Aspirin is the best known anti-inflammatory drug, acting to inhibit cyclooxygenase, leading to subsequent reduction in prostaglandin (PG) synthesis [1]. PG, especially PGE2, stimulate adenylcyclase, and cAMP inhibit the synthesis of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), two cytokines which contribute to inflammation [2]. Most studies investigating the effects of inhibitors of PG synthesis [...]