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Oral magnesium supplementation improves borderline hypertension


Magnesium Research. Volume 24, Numéro 1, March 2011, Letter to the editor

DOI : 10.1684/mrh.2011.0273


Auteur(s) : Klaus Kisters, Medical Clinic I and ESH Excellence Centre, St. Anna Hospital, Herne, Germany.

ARTICLE

mrh.2011.0273

Auteur(s) : Klaus Kisters kisters@annahospital.de

Medical Clinic I and ESH Excellence Centre, St. Anna Hospital, Herne, Germany

Correspondence. K. Kisters, Medical Clinic I and ESH Excellence Centre, St. Anna Hospital, Hospitalstr. 19, 44649 Herne, Germany

Dear Sir,

We read with interest the recent paper of Barbagallo et al. entitled “Oral magnesium supplementation improves vascular function in elderly diabetic patients” [1].

The authors conclude that an oral magnesium therapy positively influences brachial artery endothelial function in elderly diabetic hypertensives. In this context it is well known that endothelial function has been consistently found altered in hypertension, representing an early indicator of atherosclerosis, associated with an increased incidence of vascular diseases in this condition [2]. In this process a magnesium deficiency often occurs and can be a pathogenetic factor due to e.g. disturbed transport systems or transmembrane defects [3, 4].

Furthermore the authors describe a positive effect of an oral magnesium therapy on blood pressure (BP) lowering (systolic BP decreases from 150  + 7 to 148  + 5 mmHg and diastolic BP from 82  + 5 to 79  + 5 mmHg [1].

In a recent paper from our group we describe the similar effect of an oral magnesium therapy in blood pressure lowering in borderline hypertensive patients. We studied 18 untreated borderline hypertensives versus 35 controls under a 12–15 week supplementation with 240-500 mg magnesium orally/day. Systolic and diastolic blood pressure values of the borderline hypertensives normalized after oral magnesium administration (before therapy: 147.6  + 8.5/87.2  + 4.4 mmHg; after therapy: 137.2  + 4.6/83.8  + 3.4 mmHg, p< 0.05) [5].

In several previous studies the positive effect of a magnesium therapy on blood pressure or endothelial function has been described [6, 7].

Concerning borderline hypertension, magnesium status has not been studied in detail, yet. The data by Barbagallo et al. and our own recent results show that magnesium deficiency in borderline and mild hypertension (WHO degree I) should be corrected to normalize blood pressure values and thereby a positive effect on endothelial function can be observed consecutively.

References

1 M Barbagallo, LJ Dominguez, A Galioto, A Pineo, M. Belvedere Oral magnesium supplementation improves vascular function in elderly diabetic patients Magnes Res 2010; 23: 131-137.

2 Seelig M. The Magnesium Factor. New York: Penguin Group Inc, 2003.

3 LM Resnick, O Bardicef, BT Altura, MH Alderman, B.M. Altura Serum ionized magnesium: relation to blood pressure and racial factors Am J Hypertens 1997; 10: 1420-1424.

4 K Kisters, F Wessels, F Tokmak, ER Krefting, B Gremmler, M Kosch, M. Hausberg Early-onset increased calcium and decreased magnesium concentrations and an increased calcium-magnesium ratio in SHR versus WKY Magnes Res 2004; 17: 264-269.

5 Kisters K, Nguyen MQ, Gremmler B, Funke C, Hausberg M, Tokmak F. Magnesium therapy in borderline hypertension. Trace Elem Electrolyt 2011.(in press).

6 M Shechter, M Sharir, MJ Labrador, J Forrester, B Silver, C.N. Bairey Merz Oral magnesium therapy improves endothelial function in patients with coronary artery disease Circulation 2000; 102: 2353-2358.

7 Y Rayssiguier, JD Mbega, V Durlach, E Gueux, J Durlach, J Giry, M Dalle, A Mazur, P Laurant, A. Berthelot Magnesium and blood pressure. I. Animal studies Magnes Res 1992; 5: 139-146.


 

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