Magnesium and the control of cell proliferation: looking for a needle in a haystack

Illustrations

Figure 1 Possible mechanism of low Mg-dependent growth arrest in diploid cells. Oxidative stress-mediated up-regulation of cell cycle inhibitory proteins through a p53-dependent mechanism or through other pathways such as NFkB, stress signals or gene expression.

Figure 2 Possible mechanism of low Mg-dependent growth arrest in immortalized or transformed cells. The oxidative stress-mediated signals cannot be ascribed to p53 activation, but to other pathways where low Mg may affect directly or indirectly up-regulation cell cycle inhibitory proteins.