Auteur(s) : Jean Durlach, Nicole Pagès, Pierre Bac, Michel Bara, Andrée Guiet-Bara , Université Pierre et Marie Curie, Paris VI, 75252 Paris Cedex 05, France, Laboratoire de Toxicologie, Faculté de Pharmacie, Strasbourg, 67400 Illkirch-Grafenstaden, France, Laboratoire de Pharmacologie, Faculté de Pharmacie, Paris XI, 92290 Chatenay-Malabry, France, Laboratoire de Physiologie et Pathologie, UPMC, 75252 Paris Cedex 05, France.
Illustrations
Figure 1 Clinical forms of magnesium depletion
with hypofunction of the biological clock (hBC).Magnesium depletion
with hBC is due to the sum of a nutritional deficit: magnesium
deficiency and of a chronological disorder due to either primary:
hypothalamic or pineal lesions or secondary: to light
hyperstimulating effects (clinically with photophobia). This
disorder may induce various psychic, hypnic, neuromuscular or algic
disorders: i.e. headache with photophobia (migraine
particularly).
Figure 2 Migraine due to magnesium depletion
with hypofunction of biological clock by photic
sensitizationSubcortical and cortical genetic factors further the
development of a magnesium depletion caused by a deficient
magnesium dietary intake (magnesium deficiency) plus a photic
stress (mainly circadian: diurnal; and seasonal: during «fair»
seasons) with reactive photophobia and more or less generalized
[sensory, cognitive, painful (trigeminal particularly), alimentary]
sensitization. It induces cortical and subcortical dysexcitability
and spreading oligemia and depression in clinical form with aura.
Between migraine and headaches with light hypersensitivity there is
a continuum of varying severity.
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