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The -2518 A/G polymorphism in the monocyte chemoattractant protein 1 gene is associated with the risk of developing systemic lupus erythematosus in Argentinean patients: a multicenter study |
European Cytokine Network. Volume 23, Numéro 1, 7-11, March 2012, Research article
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Auteur(s) : Federico Aranda, Silvia Perés Wingeyer, Sebastián Andrés Muñoz, Alberto Allievi, Alberto Orden, Rosana Trobo, Analía Alvarez, Alicia Eimon, Juan Carlos Barreira, Emilce Schneeberger, Judith Sarano, Julio Hofman, Gabriela de Larrañaga |
Résumé : Systemic lupus erythematosus (SLE) is a systemic, autoimmune disorder. Monocyte chemoattractant protein 1
(MCP-1), a chemokine involved in the recruitment and migration of monocytes/macrophages, has been shown to be increased in the plasma of SLE patients. The aim of our study was to evaluate the possible association of the polymorphism -2518 of the MCP-1 gene with the risk of developing SLE, manifesting lupus nephritis (LN) and with other clinical features of SLE in an Argentinean population. A group of 171 SLE patients and 120 control subjects were examined. Genotypic and allelic frequencies of the MCP-1 -2518 A/G polymorphism showed significant differences between the SLE and the control groups (p\=0.001 and p\=0.01, respectively). However, the polymorphism showed no association with LN or with the other clinical variables studied. Our results suggest that the presence of the MCP-1 -2518 A/G polymorphism might be a risk factor for developing SLE in genetically predisposed individuals, but it does not seem to have a role in the evolution of the disease in the Argentinean population. |
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