JLE

European Cytokine Network

MENU

Stromal cell‐derived factor‐1 (SDF‐1)\CXCR4 couple plays multiple roles on haematopoietic progenitors at the border between the old cytokine and new chemokine worlds: survival, cell cycling and trafficking Volume 15, numéro 3, September 2004

Auteurs
Département de Recherche, Centre de Transfusion Sanguine des Armées Jean Julliard, 1 rue Lieutenant Raoul Batany, BP 410, 92141 Clamart Cedex, France Laboratoire d’Hématopoïèse, Inserm‐ESPRI‐EA3249, Faculté de Médecine, 2, boulevard Tonnellé, 37032 Tours Cedex, France Institut National de la Santé et de la Recherche Médicale, Unité 602, Institut André Lwoff, Hôpital Paul Brousse, 14, avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France

Generation of haematopoietic cells is regulated by cellular and humoral interactions in which stromal cells, adhesion molecules, cytokines and chemokines play a crucial role. Among the chemokines, SDF‐1 and its CXCR4 receptor have been reported to be key players in the nesting of haematopoietic progenitors within the bone marrow. Disruption of the SDF‐1\CXCR4 axis results in cell mobilization and may participate in leukaemia extramedullary infiltration. In this review we will discuss the manifold roles of the SDF‐1 chemokine and of its receptor in haematopoiesis regulation. By recruiting quiescent progenitors, by participating in their survival\cycling and by sensitizing them to further cytokine synergistic action, SDF‐1 likely contributes to haematopoiesis homeostasis under physiological conditions and in stress situations. The complexity of the SDF‐1\CXCR4 interactions in the regulation of haematopoiesis illustrates a dynamic and sequential cross‐talk between chemokine and cytokine\growth factor worlds. Because of their pleiotropic effects on haematopoietic progenitor trafficking, survival and proliferation, the SDF‐1\CXCR4 couple could be considered as promising molecules for improvement of cell‐based therapy protocols in haematopoietic transplantation.