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Can interleukin-10 be used as a true immunoregulatory cytokine? Volume 11, numéro 2, June 2000

Auteurs
INSERM U. 343, Hôpital de l’Archet, route de Saint-Antoine-de-Ginestière, 06200 Nice, France.
  • Page(s) : 153-60
  • Année de parution : 2000

INTRODUCTION The discovery of IL-10 emerged simultaneously from two independent research pursuits. One of these, identified a B-cell-derived mediator which co-stimulated proliferation of activated thymocytes [1]. The other identification of IL-10 developed from a study of helper T cell heterogeneity and an appreciation that different T helper cell subpopulations (designed Th1 and Th2) regulate either cell-mediated or antibody-mediated immune [...]